Buy Buspirone (Buspar) tablets onlineHow and where to order Buspar (Buspirone Hydrochloride) 5 mg, 10 mg tablets or capsules online:
Indications and usage:
BuSpar (Buspirone Hydrochloride) is indicated for the management of anxiety disorders or the short-term relief of the symptoms of anxiety. Anxiety or tension associated with the stress of everyday life usually does not require treatment with an anxiolytic.
BuSpar is contraindicated in patients hypersensitive to buspirone hydrochloride.
Dosage and administration:
The recommended initial dose is 15 mg daily (7.5 mg b.i.d.). To achieve an optimal therapeutic response, at intervals of 2 to 3 days the dosage may be increased 5 mg per day, as needed. The maximum daily dosage should not exceed 60 mg per day. In clinical trials allowing dose titration, divided doses of 20 mg to 30 mg per day were commonly employed.
The bioavailability of buspirone is increased when given with food as compared to the fasted state. Consequently, patients should take buspirone in a consistent manner with regard to the timing of dosing; either always with or always without food.
Dosage forms and strengths:
BuSpar (Buspirone Hydrochloride) tablets for oral usage, 5 mg and 10 mg.
Signs and symptoms
In clinical pharmacology trials, doses of Buspirone HCl as high as 375 mg/day were administered to healthy male volunteers. As this dose was approached, the following symptoms were observed: nausea, vomiting, dizziness, drowsiness, miosis, and gastric distress. A few cases of overdosage have been reported, with complete recovery as the usual outcome. No deaths have been reported following overdosage with BuSpar alone. Rare cases of intentional overdosage with a fatal outcome were invariably associated with ingestion of multiple drugs and/or alcohol, and a causal relationship to buspirone could not be determined. Toxicology studies of buspirone yielded the following LD50 values: mice, 655 mg/kg; rats, 196 mg/kg; dogs, 586 mg/kg; and monkeys, 356 mg/kg. These dosages are 160 to 550 times the recommended human daily dose.
Recommended overdose treatment
General symptomatic and supportive measures should be used along with immediate gastric lavage. Respiration, pulse, and blood pressure should be monitored as in all cases of drug overdosage. No specific antidote is known to buspirone, and dialyzability of buspirone has not been determined.
The administration of BuSpar to a patient taking a monoamine oxidase inhibitor (MAOI) may pose a hazard. There have been reports of the occurrence of elevated blood pressure when BuSpar (buspirone hydrochloride) has been added to a regimen including an MAOI. Therefore, it is recommended that this drug not be used concomitantly with an MAOI.
Because buspirone has no established antipsychotic activity, it should not be employed in lieu of appropriate antipsychotic treatment.
Information for patients:
To assure safe and effective use of BuSpar, the following information and instructions should be given to patients:
Use Buspirone tablets with caution with these products: psychotropic agents (MAO inhibitors, amitriptyline, diazepam, haloperidol, nefazodone, trazodone, triazolam, flurazepam), inhibitors and inducers of CYP3A4 (diltiazem, verapamil, erythromycin, itraconazole, nefazodone, rifampin, ketoconazole, dexamethasone, phenytoin, phenobarbital, carbamazepine, ritonavir, grapefruit juice), cimetidine.
Eszopiclone (Lunesta, Lunivia)
Adverse reactions, side effects:
The more commonly observed untoward events associated with the use of BuSpar pills not seen at an equivalent incidence among placebo-treated patients include dizziness, nausea, headache, nervousness, lightheadedness, and excitement.
Drug abuse and dependence:
Controlled substance class
BuSpar (buspirone hydrochloride) is not a controlled substance in most of countries worldwide.
Use in specific populations:
No fertility impairment or fetal damage was observed in reproduction studies performed in rats and rabbits at buspirone doses of approximately 30 times the maximum recommended human dose. In humans, however, adequate and well-controlled studies during pregnancy have not been performed. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.
Labor and delivery
The effect of BuSpar (buspirone hydrochloride) on labor and delivery in women is unknown. No adverse effects were noted in reproduction studies in rats.
The extent of the excretion in human milk of buspirone or its metabolites is not known. In rats, however, buspirone and its metabolites are excreted in milk. BuSpar administration to nursing women should be avoided if clinically possible.
The safety and effectiveness of buspirone were evaluated in two placebo-controlled 6-week trials involving a total of 559 pediatric patients (ranging from 6 to 17 years of age) with GAD. Doses studied were 7.5 mg to 30 mg b.i.d. (15–60 mg/day). There were no significant differences between buspirone and placebo with regard to the symptoms of GAD following doses recommended for the treatment of GAD in adults. Pharmacokinetic studies have shown that, for identical doses, plasma exposure to buspirone and its active metabolite, 1-PP, are equal to or higher in pediatric patients than adults. No unexpected safety findings were associated with buspirone in these trials. There are no long-term safety or efficacy data in this population.
In one study of 6632 patients who received buspirone for the treatment of anxiety, 605 patients were ?65 years old and 41 were >= 75 years old; the safety and efficacy profiles for these 605 elderly patients (mean age = 70.8 years) were similar to those in the younger population (mean age = 43.3 years). Review of spontaneously reported adverse clinical events has not identified differences between elderly and younger patients, but greater sensitivity of some older patients cannot be ruled out.
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